Schizophrenic disorders are characterized by perceptual changes (hallucinations) and thought disorder (delusions). These are pellagra syndromes, including Huntington’s disease, some Parkinsonism patients, schizoaffective patients, and LSD induced psychosis. I consider these conditions variants of pellagra. Schizoaffective patients have mood swings, and during their manic states will also have schizophrenic symptoms. These pellagra variants are responsive to vitamin B3 when adequate doses are used. They will not respond to small doses or to other nutrients. They are B3 dependent conditions, and should not be considered as deficiency diseases.
—ABRAM HOFFER, M.D., PH.D.